Almost 30 years of reloading for me, all centerfire rifle. Mostly in search of ultimate precision.
I've found best results by selecting a powder that mostly fills the case, and is normally considered by many sources or manuals to be a good powder for that particular cartridge. I stick with that powder unless results indicate a reason to change.
Next, I'll buy a few different bullets that will be acceptable for my uses.
Then, I'll load a few charges from the books with each bullet. Might end up with 3 or 4 powder charges with each of the 3 bullets I've selected. Remember to work up toward maximum powder charges with caution.
I will seat these bullets at or within .030 of the rifling for preliminary tests.
I will shoot all 9 or 12 groups under good calm conditions. Making sure I do everything possible to make each shot my best.
You may find that your rifle really prefers one particular bullet, if so go with that one. If it's not picky then it doesn't really matter, which is nice.
Now that you've decided on a bullet that shoots decently from your gun, next step is either test seating depth or powder charge variations. I personally test powder charges first, looking for the band or range that exhibits the best grouping with minimal or no change in point of impact between charges. Once this is found, you've now got your bullet and your powder charge.
You may find this to be an acceptable place to stop testing and start shooting LR. Or, if you want to, you can test different seating depths with your already selected bullet and powder charge, looking for the best groups.
You can get as deep into reloading as you'd ever want to and still never know it all, nor tested every component, nor used every nifty cool tool thats available. At some point for hunting, it's gotta be "good enough", or you'll have the barrel shot out before you ever take any game.
My most recent rifle purchase was a 6.5-284. I started with one powder and one bullet, working up to where I got the best groups with acceptable speed.
I then tried a few different seating depths at a longer distance, and stuck with the one that shot best. I called that "good enough". It's a light rifle, but when I do my part it will shoot under 1/2 MOA out to at least 800 yds, probably further but I haven't stretched it out yet. Light rifles are tougher to shoot good groups with IME.
Below is the first group shot at 700 yds after going through the above steps with this rifle. 1/2 MOA is kinda the goal for a LR rifle, Maximum of 3/4 MOA. My personal goal is 1/4 MOA, but thats not always attainable with a hunting gun.
Dont be afraid to ask questions, the deeper you get into reloading, the more you'll have. BestoLuck