I am going to go way out on a limb and say that it would be worth trying.
Looking through Hodgdon's data it looks like it pretty much kicks but on everything they list loads for the 100v. Until I try it though I will remain cautiously optomistic, all one can do is try it and see how well it shoots. You posted that you use RE 22. I have never been able to get any Alliant powder to shoot well in any of my guns and many others have great luck with it, which is why I say you just need to try it to know how it will perform.
I did notice when looking up load data for the 280 that all load pressures, including Hybrid 100v and Supreme 780 are in CUP for that ctg.
I am sure that Hodgdon will list it as an extreme powder, it will be interesting to see if it is as temp. stable as H4350 'tho I doubt it will be.