This is in no way advice but if it where me and I had the amounts of R22 you mentioned they would get mixed very well into one lot. R22 is the powder that taught me to start low and work up...even when you are just switching lots or primers!! That slow lot many years ago sure shot great but man what an eye opener when I bought new powder
__________________ "Make everything as simple as possible, but not simpler." -Albert Einstein (1879-1955)
Been doing it for 20 years with 20 different typres of powders. As the previous poster said, I believe if variations exist it probably mellows them considerably. Probably not a good idea if you are running loads at or over max.........YMMV.