My first one, a factory Remington, lived on H4831 and 220 grain Sierras. Took elk and Namibian plainsgame with it. Still have it but it's pretty well retired for now.
The second one was a Model 70 with a PacNor barrel...it liked Reloader 25 and the discontinued 220 Barnes X. I used it on some more plainsgame and the usual deer and coyotes. The 220 Swift A-Frame worked great also.
I never used any of the lighter bullets, as most are designed for 8x57 speeds and will probably lack penetration on the bigger stuff. But to disassemble coyotes...