moooo (making herd murmuring noises)
The way I do it is to run an Audette at 300 yards. That is to load each case with a progressively higher powder charge. The point of impact will progressively rise and theoretically there will be 3 or 4 shots that level off and group closer. Sometimes it seems to work but it is like reading tea leaves
My main purpose is to find the velocity I want. Then I load sets of 4 or 5 shots at different seating depths to look at the accuracy
Varying seating depth will change the velocity and the timing of the muzzle exit but to a lesser degree than varying powder charge. So IMO powder charge is macro tuning and seating depth is fine tuning.
IME it is 2 variables both of which have an effect on accuracy and a variation in powder charge or seating depth will change group size and POI.