What are you hunting? This is my go to hunting rifle I shoot deer, varmints and targets with my sendero. All my good loads are and have been with IMR-4350. I have tried 4 or 5 different powders but always go back to 4350. I shoot 100 grain bullets or less.
Deer- I shoot Sierra Pro-hunters 100 grain flat base.
Varmints- Can't beat 75 grain V-max for pure explosiveness, I own 10 boxes.
If for some reason the 75 grainers don't shoot, try the Speer 87 grain TNT.
Targets- I havent got the Berger 115 vlds to shoot yet, still trying. But have had real good results with Sierra Matchkings 100 grains, they shoot great out to 1000 yards and are still above the speed of sound.
For brass you can also use Norma 270 brass trimmed down to 25-06 length, I have had great luck with my gun.