Have used 140's exclusively...started with the Remington factory loads because I bought the rifle during PA bear season in 2000 I think....it was right after they came on the market. Killed a couple of does that year all was well. Then started looking for reloading "stuff", tried some 140 Barnes XLC because I had a couple hundred on hand. Barnes load recommendations with H380 put them all over the target. Scrapped. Then used some Hornaday 139 Light Mag...groups about 2 inches, but sure killed the deer right now. Got an honest 2950 fps with these. Really had problems obtaining any suitably accurate load, so I did the Tubbs 50 round fire polish and then things started to come around. It still doesn't like the Lite Mags but groups are closer. Tried the Sierra 140 Pro Hunter because it will accommodate the short OAL due to flat base and traditional lead core. 42 gr gives me around 2660 fps, essentially a one hole. Planning on going up to about 44-45 to see if there is another node. I will sacrifice a bit of group size for fps because This is my all day carry, or my 280 Mtn, for PA deer and bear.
I have modified the rifle, McMillan Hunters Edge stock, bottom metal from Brownells to make it a BDL, never really liked the blind magazine, and a Jewell trigger. Ready to go, right at 6 pounds. At my age, that's enough. Sorry for the long winded reply, in short speak, 140's have done quite well in this rifle.
See you are from PA.....what part, I was born and grew up near Pittsburgh, and lived in "Little Washington for over 40 years. Retired to FL, now come back every fall for the "hunt"!!!!