I use Benchmark(ADI Benchmark 2) for .223 light bullets and Varget(ADI 2208) for .22-250 50gr. Both are Extreme Extruded powders from ADI in Australia. They are advertised as less temp. sensitive than other brands.
Benchmark should work just fine with .22-250. It is a very flexible cartridge.
For me, Benchmark is easier to meter in powder dropper than Varget.
Hodgdon - The Gun Powder People
has load data and info on the powders.