Re: Help with a 1 in 14 22-250
You might want to look at 55gr hornady with a canular. It's tougher than it needs to be which is why I stopped using it, it didn't give me the red mist on gophers. I was loading it with 41gr(if memory serves) H380, and a CCI250(the only primer that would produce good groups for me). The cases didn't seem to matter all that much. the bonus is it's a really cheap bullet hat shoots fairly well.
Keep in mind the animals we shoot for food and display are not bullet proof. Contrary to popular belief, they bleed and die just like they did a hundred years ago. Being competent with a given rifle is far more important than impressive ballistics and poor shootability. High velocity misses never put a steak in the freezer.