Chris, Not knowing the details of your rifle, factory bolt action, custom barrel, and etc makes it a little more challenging to offer advise.
I have owned two 270 Win's in my time. I reloaded for both. I have excellent results using the Sierra 130gr SBT Gameking bullet myself. But these days, I think the newer plastic tip bullets might be a better choice. If you can get the Nolser Accubond to shoot, that may be a good choice.
I used IMR4350 in my M700BDL (22" bbl) and that rifle shot very well. It was shooting 3025 fps and 3/4 moa.
In my Tikka T3 Lite (22" bbl) I got on the band wagon and I am using H4831SC. I had to stop at 59.4 grs of powder, RP Brass, CCI200, 130gr SPBT. This rifle shoots 2930 fps and 1/2 moa. This is a max load for this rifle and that is where I had to stop.
Some guys are getting over 3100 fps - I have never been able to push any of my factory 270 with a factory barrel up there. the alias you chose indicates you understand the need to stop at the group minimas versus stopping just prior to the primers falling out of the brass.
A lot of guys are having excellent results with RL-22. Don't overlook that powder.