Re: Did I hurt my Barrel
You need to get a program and stick with it. You have too many components, brass and propellants. Settle on a powder and case(?) probably 760(?), or 414, & back off 1˝-2 grains from where you blew the primer. You aren't using mag primers, are you? I suggest switching to 55 gr. VMax, the 22-250AI deserves a heavier bullet. Also, yes you could be "hurting" your barrel if you continue to fire X number of primer piercing loads. Do you see excessively flattened or cratered primers, or a black ring around the primers? Excessive pressure, you could get premature throat errosion, and degraded accuracy. Excessive pressure in that case will show up as loose primer pockets, when you seat a new primer. Where are you at, with bullet seating? I don't think you are quite ready for field work, at this point.
Good luck, LB