Over the years I've loaded a lot of different bullets in a lot of different calibers. One issue that I hear pop up is either their COAL wont fit into their magazine and/or wont get close enough to the lands in their rifle. Sometimes causing their load to have the bullet deeply seated into the case. Which I have noticed myself and either tuned the gun any way or looked for another bullet that fit the criteria and the case as well.
This is something that has kept me from using more then a few bullets in various calibers as of late. A lot of them are geared towards the heavy for caliber end and the high BC that comes with that. What I've noticed is that the tuning becomes far easier and the results better when the bullets aren't seated so deep into the case. And that last powder that worked for you in one weight bullet so well should work for another bullet in that weight class just as good, maybe.
Look at the first photo, here you'll see (4) bullets in one small cluster, looks like three but that's four bullet into that hole. You'll see on the paper roll from my Oehler that there was a total of (7) shots fired. The other larger group was fired from 300 yards, but I got the dope a little wrong. They were suppose do be dead center. This load only took two rounds to check the speed and the other five to check the load for accuracy. So you can see without a lot of fuss another load can be developed with out too much trouble if you had another load that worked before and switched the bullet with minor changes in powder charges made.
Seating depth can and does make a difference to load development for accuracy, and if you can run them close enough to the lands as the throat wears out you can chase the lands later on. I was going to chime in on another post about the importance of seating depth as well as which powder is being used in combination with the bullet to produce an accurate round, but I thought I'd stay out of it in that post. But I do have some results from this past two weeks in two different guns that show the same results. Getting the bullet close enough to the lands and avoiding a bullet that's too long for the case.
Photo #2 shows a loaded 7mm-08 round with a 168 grain Match King and that same bullet next to it showing the seating depth in the case.
In Photo #3 a different gun was used, a 6.5/300 WSM
using a 140 Match King where the bullet is seated in the same position as the 7mm-08 round with the 168 SMK. What you'll see is the difference of only 0.010" in seating depth between the two groups. Nothing else was changed other then the seating depth. This is another load were I already had a great load using a hunting bullet, a 140 SGK, and switch to another bullet in the same weight and low and behold found another load only using ten rounds. The better group was BTW seated off the lands the same as the hunting bullet I had already developed.
Hope that helps about any deep seated fears you might have lurking in your minds, but in the end nothing is cast in stone. These are my own observations and what I have noticed is that deeply seated bullets can cause some issues other then how long the magazine box is, and bullet jump can make a difference in a loaded round for accuracy.
On another note, I've found the best accuracy near the upper end in terms of velocity (pressure), and avoided the mishaps that can happen when using the hottest loads due to temperature and elevation changes that can and do cause problems.