I'v used compressed loads for my 220 Swift never had a problem. I just never found them to be the most accurate for my gun. I plan to start loading for my 22 Hornet from what I'v read most of the good loads are compressed. Some by as much as 110%. I'll try them.
My observation is that I get lowest velocity standard deviation with loads between 95 and 98 % case fills. Within that range I use ladder tests at the rifle's maximum useful range for smallest groups. I don't tune for short range groups. I also keep my loads under 90% of SAAMI max pressure with modern cartridges and firearms, though that's for longevity of the firearms rather than short term accuracy or energy. I just don't use cartridge/bullet/powder combinations where compressed loads are needed.