I know what you mean about frustrating. When I first encountered my runout problems w/ the 250, I made a concentricity guage using an old dial calaper and some scrap wood and epoxy (pretty much jerry rigged but it works). Then I purchased a $99 redding comp seating die and was astonished to see runout yet. Then I turned necks and resized agian ---> still had runout! Next I fired the rounds and then resized them agian, No runout. So, I'm not certain if the turning really did it or if it was a combination of many factors.
I have been finding that with my rifles (all factory rem, Tikka, Savage, winchester) one of the biggest factors that helped me gain accuracy was creating a crush fit when chambering the rounds. I am not able to seat to the lands on any of my rifles so I have to rely on the case itself to perfectly center bullet to bore. I have started PFL resizing and have good results so far. For my WSM's I have comp shell holder set which is nice, but for my 250 I am simply backing the die off a little. I would like to simply neck size but I find that after a couple loads both my 22-250 and my 300 wsm
get really sticky bolts and the groups go the heck at that point too. So, I have been simply PFL sizing all the time. Probably a little harder on the cases, but I want accuracy and reliability --kinda obsessed with it lol!