I tried RL17, Retumbo and H1000 in my 25-06. On the Nosler site, the Retumbo was the highest velocity powder they listed fpr 110 gr bullets. RL17 beat it by about 200 fps in my Sendero. I got 3500 fps with 55 gr/110 AB's and no pressure signs.
It also beat H4350 by 200 fps in my 300 WSM
with 67.5 gr/180 E-Tips.
I found the Alliant max loads 1-3 gr light in *MY* rifles.