Loading to the maximum length (touching the lands) really doesn't leave very much capacity for the RE 17 in my Lapua cases. 44 grains was no problem, 46-47 required more powder compression than I'm comfortable with and 48gr was out of the question (for me).
I'll shoot the 44-45-46 & 47gr. loads just for the heck of it but unless you are throated loooong I don't see how the combo is a viable option.
Maybe some 185 VLD's and a faster powder would be a better option in my rifle.