Re: 280 Ackley.......heavy bullets?
My dad and I each have a 280 Ackley. We are both shooting the 168 bergers. I don't think it would handicap you at all..in fact I think it would help. I looked into trying the 140 bergers this summer, but with the lower BC, we couldn't push them fast enough to make up the energy difference to the 168's once you hit 400-500 yards.
I shot 2 elk this year with them at very close range, and they performed great. Have shot at total of 5 deer and 4 antelope over the last 2 years with them also..all one shot kills.