If you're milking the Nth degree of velocity Norma MRP, N205, RE-22 and some are using 7828ssc with 150 class bullets.
If not pushing but looking for moderate range accuracy, any of the above powders loaded down a bit and 4831 around the 60 grain mark should produce accuracy.
I'm a velocity hawg with the little winnie pushing the 140s @ 3200 with Reloder 22, in the summer time. Temp drops it a bit in winter. But it shoots very well at that velocity and good for out to 800 yards or so.
I may be the slowest guy on the mountain . . . . but . . . . I'm on the mountain!
It's(h1000) a bit slow in the 270, but you can't go over pressure with it to easily either. My brother had a Retumbo load for his 270 win and I currently have a wc872 load for mine, and both shoot very well, albeit at slightly lower velocities.
The previous poster must have a fast rifle as I've not gotten over 3100 fps with any hunting weight (130 gr. or more) bullet in either of my 270's; or he's on borrowed time before he loosenes his headspace up. Either way, 3K on a 140 is about it unless you have a wsm.
I've used I 7828 with 140's in mine with good results.