Re: 22-6mm ack.
+1 on what Petersen said. If you're hell bent on an overbored .224 cartridge there are few that make more sense (overall) than the 22-243 (plain).
High quality brass is easy to find and easy to neck down with no fireforming which wastes barrel life unless you use cream-of-wheat or a similar method. There is also the rule of diminishing returns involved here. You will have to burn a lot of extra powder in a larger case just to see a slight increase in velocity. At the current cost of a new custom barrel with all the machine work done, a thousand round gun is hard to swallow. I've shot out several custom hot rods, and while it was a lot of fun, the fun didn't last long.
A case as big as the 6mmAI or 284 might be a better choice if 100gr bullets and appropriate powders were available and/or desirable. But that's taking wildcatting to the next level.
I'm starting to go back to the basics and life is certainly getting easier and less expensive.