My 14 twist 26" tube likes several diff loads:
52 Amax, 55 NBT, and 55Bks all do very well in front of 38g H4350 or 32.5g AA2015. My second favorites would be H4895 and Varget.
These are 1/4MOA in this rifle, but you'll have to find the sweetspot in yours.
The 22-250 works well with many different powders, but if I had to pick a couple to start, I'd go with Varget and H4895 as they seem to be good in every 22-250 I've loaded for.