The only bullet I've found in the 22-250 to defy the rule in a 1-14 is the Speer 70 Semi Spitzer.
I just did custom loads for a fellas Lightweight M70 and the Speer 70 out shot everything. Many of the 50-55s I shot through that rifle shot plain terrible groups in the 2-2.5" range [img]/ubbthreads/images/graemlins/crazy.gif[/img] but, finally the 70 Speers were able to save the day so to speak and print around 3/4" at 100 which isn't great but much better than the ridiculous groups the factory ammo was printing for him as well as the pile of handloads I tried. I loaded up another 25 last night and hope they do ok out at 200 which is about all he needs for yotes and hogs where he'll be using it.
Several other shooters put me on the Speer 70s saying they'd shot well from a 1-14 in their experience. I may have to try them in my XR100 22-250 just to see what happens.
The speer 70s are not hardly a match bullet and they certainly don't have the greatest BC at only .214 but, if you do want to push alittle heavier bullet from your 1-14, they may be a good place to start. Probably be much better construction wise for medium game as well.