Thanks Esshup!!
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For me, some of the criteria were:
How heavy of a gun am I willing to live with? --I'd like it to be a carry gun, I can pack a stout load though, so maybe ~18 lbs...less would be nice, but I'm after accuracy too
How much recoil am I willing to take at the bench and at practice? --not a problem here...
What will I be using it for? i.e. will I have to carry it for any length of time? --hunting and target shooting out to 1k...
What critters will I be using it on? --everything

(hence, the .375 caliber)
How many shots per year do I plan on running thru it? --100 to 200...maybe a few more
How much time and effort am I willing to spend reloading for it (that's also including the time to prep the brass if not an "off the shelf" cartridge). --I love the hobby of reloading, so this would be a hooooot!
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Thanks again!