I built my 280 rem for exactly the sort of distance you are talking about, and, as these things do, it now has changed a bit. I have a 700BDL with a 25" medium contour barrel, Evolution Gun Works 15MOA rail and a IOR 3-18 in low rings- it all works just fine, and I can't say enough good things about the scope.
The load is a 162 AMax at 2850 or so, and I find it works very well on deer. I chose the 280 over the WSM due to having a limited choice in left hand actions at the time (the Savage wasn't out then) and wanted something that would be dead reliable in feeding, as I shoot a lot of goats with this rifle and as a bonus the cheaper brass means you don't cry when you loose a few in the long grass.
Good luck with the build.