Yes, the faster twist will stabilize the heavier bullets in the 22 cal. but not the heaviest. At 300 yds the 22-250 is a not all that far. I shoot 55-69 gr in my custom 24" AR/223. I am far from the most knowledgeable on the site, but might be able to point ya in right direction. The Google search is custom for this site in top right corner of page. In the coyote hunting
section you'll find what a lot of guys are shooting and some tips. Welcome aboard!