Re: I think I like this!!!
What bullet will you be shooting and what twist is the rifle. I believe you'll find that the 22-250 (factory) will be a slow twist designed for light fast bullets. With a light fast bullet you'll be having a rough time at 1000 yards, you may do better to shoot the 223 for long range (if it's a fast twist barrel) and use the 69 Sierra, 80 Sierra or the heavier A-Max.
I was assisting at a Varmint hunters long range course last year (first one offered at this particular facility) and many folks were very disappointed in the performance of their varmint rifles once the range exceeded 450 yards. Rarely (if ever) did anyone hit the 720 tard target with a light fast (.22 cal) bullet.