Re: First varmint gun.
If I were you I'll choose 223 Remington rather than 22-250 for your first Varmint gun. If you compare the two, you'll find out that the 22-250's advantage were few and far between. With carefull handloading, you can streach the performance of the 223. If you want speed, go up a notch and get a 6MM round. As for what brand, that depends on your budget. Kimber is great. Weatherby Varmintmaster is excellent. Remington, Winchester, Ruger are so so. For out of the box accuracy, Savage are hard to beat.
To achieve the maximum possible accuracy, all variables must be remove or at least minimize.