Re: 22/243 rifle:
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Assuming that you have a fast twist barrel (8") you can save lots of time, money and throat wear by starting with RE22 and using 80gr SMK's or 75gr A-Max bullets. Other powders may work too but RE22 seems to be accurate and fast in all the 22/243 guns that I am familiar with.
With an 80gr bullet you will peak out at around 47 grains. I'd start with 10% less and work up while breaking in your barrel.
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According to Quickload, RE-22 tops out around 44gr with the 75gr A-max. 47grains is a compressed load with a load density around 109% and WAY over pressure.
Be careful, different seating depths and brass thicknesses can change pressures drastically.
According to Quickload, a MAXIMUM load of 44.8gr of RE-22 gives a velocity of around 3380fps for the 75gr A-max and a 24" barrel (COAL 2.65") (105% load density).
I have no direct experience with the 22-243, just plugged the numbers into Quickload for you.
Hope this helps,
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