Originally Posted by Greyfox
For my favorite sport, long range deer, antelope , and coyote hunting, the most accurate cartridge I have used out to 1000 yards would have to be the 6.5x284. The rifle that impresses me most is an original Remington 1903 A3 made in 1944. i have owned it for many years, bone stock with original trigger and a peep sight, Shoots a little over an inch at 200 yards, 5 shots, with a Hornady Spire Point 150 gr bullet and 52 gr.of IMR 4350. I have a warm spot for this rifle and it would definitely be the last to go. Makes me sometimes wonder about all the time and money I have spent on playing with bedding, barrels, triggers, etc.
My 243 is like that, it's a Rem 788, I've found some loads it just did not like, most of the time though it shoots anything I feed it as long as the components are 1/2way decent.
To answer the question, it's a 3way tie between the 22-250, 243 and 7mag. 243 might win out if I changed out the stock trigger with a timney.
Keep in mind the animals we shoot for food and display are not bullet proof. Contrary to popular belief, they bleed and die just like they did a hundred years ago. Being competent with a given rifle is far more important than impressive ballistics and poor shootability. High velocity misses never put a steak in the freezer.