I would try to match the ballistics to the round I hunt with as close as possible. That way when you switch from rifle to rifle, you don't have completely different data in your head. Yeah, I know, thats what data cards are for, but I try and memorize all of my windage, drop, and come-ups for each weapon I fire.
Less variation = less confusion= more consistancy=more first round hits.
Myself, my trainer IS the rifle I plan to hunt with!