I think you need 3 fine rifles to be the complete rifleman. I know I do. All should have custom built minimum chambers and necks (necks that don't need to be turned). All should have custom actions or at least a Remington trued action. All should have custom fit/bedded McMillan or HS Precision stocks (or equal). All should have heavy bottom metal such as Badger Ordnance or the like. All should have Jewel triggers (or similar). All should have premium optics (Leupold, Nightforce, Swarovski, Ziess).
243 Win or 243AI for varmints
7mm Rem Mag or 7mm RUM for medium sized game
338 Edge (338 RUM) for everything else
These three rifles will take care of everything in North America and most of Africa. A custom rifle
can be built cheaper than most people think. Start with any of the fine barrel/action builders in the US. Then send your barreled action to a McMillan or HS precision to have the stock fitted/bedded. They can also inlet and install the bottom metal. Order and install trigger and optics yourself.
Do this and you wont end up with a safe full of factory rifles that wont shoot and you never shoot (like me). Quality rifles like these will be passed down for generations. And if you do shoot thousands of rounds through them, just have them re-barreled and go.
I built a 7mm Rem Mag using the steps prescribed above. I used a Shilen #7 contour barrel, Remington 700 trued action, McMillan Hunter stock, Badger Ordnance bottom metal with 5 shot detachable mag, Jewel trigger, and Leupold VX-III 4.5x14x50 Long Range scope
It took a year to build. Total cost was under $3000. It shoots 0.5 MOA pushing a 168 grain VLD at 3024 fps. One down, 2 to go! The 243 will be next.
5 shot group @ 100 yards