Yes it will. What kind do you have? If you don't know how to get that info out of your chrony just write it down and use Excel. You should get 2 or more charge (powder) weights in a row that are uniform (good ES) depending on how big the steps in the charges are. The bigger the steps, the fewer individual charge weights(3 shot groups) that will be uniform.
Once you find a charge weight range that's giving you some uniformity, confirm it with a 5 or 10 shot string of the same charge weight. Once you get this far, If you really enjoy tinkering, you can change your seating depth or primers to try
to make it better. This will likely force you to yet again adjust your charge weight.
Or simply call it a load and enjoy life. If you get to where you have an SD of 6 or less and you're getting decent accuracy I'd call it a load because if your like me the rifle/load combo will shoot better than you can
BTW, AJ has also given you good advise but I would consider his methods "advanced" in that he can clearly and concisely interpret his own results. I still sometimes struggle with it. What I'm telling you to do will cause you more shooting but will leave less Grey area for interpretation. At the end of the day it really doesn't matter how you get there, as long as you're there.