I've got a couple 30-06s. Heavy and light. Been shooting the heavy for over 10 years now. When it was new wiith 26" bbl, I was shooting 190 SMKs to 2920 fps, and 208s/210s at 2800 fps via RL22.
Eventually I cut my heavy to 22.5" plus a Badger brake. I'm now launching 208s at 2720 fps via RL17 and 4000-MR.
Handloading the heavy/high BC bullets you'll be about 150 fps behind the 300 WinMag with same bbl lengths. Barrel life is very good. I've got over 4000 rounds down mine and it still shoots sub-moa easily. Rifling is starting to look a little soft near the throat, but still goes all the way back.