I say you can't go wrong with either one. Both have HS stocks, and both are .300 WM with 26" stainless barrels. Both use a stainless/jeweled 700 action. The ONLY differences is one has a fluted barrel with 6-lands & grooves and has a gray/black stock, and the other uses Obermeyer 5R rifling, and has a green/black stock.
I have a 5R .308 Win, and 2 Senderos...I target shoot only with my 5R .308. And I hunt & target shoot with my Senderos.
If I had a .300 WM 5R (I'll have a barrel soon to put on my spare 700 magnum action laying around) I would most likely hunt with it, too, but I don't want to hunt with the .308 Win caliber when I have more effective long range calibers to hunt with.
Both will be equally tack-driving accurate from my experiences.
So, I guess it really comes down to fluted & gray, or non-fluted & green.
To me the 5R is more tactical, and the Sendero is more for hunting. But there's nothing wrong with either one for both.