Re: ideas for 22-250 ackley or 22-243 mid
IMO there is just no (little) benefit to using a 243 size case with .224 bullets UNLESS you shoot heavy bullets which can best utilize the extra case capacity.
I shot a 22-243AI, 8" twist, for many years. It was an incredible round for longrange groundhoggin". With 75gr-80gr bullets shots out to 1,000 were doable. If I wanted to shoot 55gr bullets I'd stick with a 22-250 size case and loose very little velocity while greatly increasing barrel life.
If you are going with a 243 or similar sized cartridge I would suggest a 22-243 (plain), no AI, Middlestead or anything else. Great brass available and no forming. Just neck down a Lapua case and go hunting. With care, you should get about 1,000 rounds of accurate barrel life. Ultimately, you could have the barrel set-back an inch or two and rechamber, thus, giving you nearly another 1,000 rounds of bore life. I did it with my 28" 22-243AI and it worked well. I did, however, rechamber to 22-243 (plain) rather than the AI configuration.