OP, Here in my neck of the woods (NE Wyo) the 22-243 is VERY popular, (yep I have one too
) Coyote hunting is taken pretty seriously by some of us & this little cartridge fits the bill nicely. The 75 & 80 Grn A-Max are THE go to bullets for pretty much everybody that shoots the 22-243 (except my rechambered 1-12 twist). As it is illegal to harvest deer, 'lopes & such with anything smaller than a 243 cal here, I cannot attest to the ability of the 22 cal A-Max to harvest deer.
I haven't heard of a single blow up or any failures to reach a target. Most velocities are in the 3500fps range safely
& they do quite well even out to 1K yds (the Wyo wind really pushes them around out there
If you do intend to harvest deer, go heavy on the bullet side.