I'm a BIG fan of that 53 Vmax bullet. It's the only bullet I shoot out of my 223AI with a 22in. Hart 1-9tw. It does do a number on coyotes! My dad, who is 74, gave one a dirt nap yesterday at just over 300yds with my 223AI and a 53Vmax.
But, I've read mixed reviews on how well they work in a 1-12tw 22-250. Seems that some people get them to shoot real well out of their 22-250 with 1-12's while others don't. I would think a 1-12tw with the launch speeds a 22-250 can produce would be enough twist but maybe for some guns it's not. I'm not sure a 1-12tw would be enough for the 53Vmax in a .223 though.
If you're looking for a slick little varmint bullet and you can make them shoot in your 1-12tw 22-250, it sure would get my vote. I wouldn't use this bullet if you were saving hides as they tend to open up real fast and make big messy holes.