Pick the bullet you WANT to shoot and the powder you THINK will give you the best in velocity and loading density
Then run an Audette's ladder (do a search) at .020" off the lands to find the powder charge that will give you the velocity you expect and make sure you are not at or over max
Then run a seating depth test to look for the best group size, extreme spread in velocity and standard deviation in velocity. For example start at .020" off the lands and load 4, then .040" off, then .060" off, etc. etc. until you reach .100" off. Believe it or not, some bullets like to be seated at a good distance from the lands.
You may have to go back and try a slight increase in powder charge if you find a load that is far off the lands and drop farther than you want in velocity. Velocity will drop the farther from the lands you load.
So I started with a bullet that I wanted to shoot - 130 gr Scirrocco II and a powder I thought would give me the best velocity with a loading density close to 90% and did the Audette's. Ran all the way up to 55 gr loading one bullet at each powder charge (not a lot of wasted bullets/powder/primers there) and found the velocity I expected and wanted without pressure signs.
Then picking the charge of 54.5 gr I did a seating depth test at .015" thru .090" off the lands. Found a decent group at .060" off with the lowest SD and ES
IOW you can get a decent load most of the time with your choices by varying seating depth as the final step