Well this may or may not help you, but it is what I went through several years ago preparing for two different hunts.
First was a trip up to WI. for whitetail using a Contender in 7x30 Waters. Knowns, low velicity impacts, realitive weights of area game around 300#, ranges from 25 - 300yds. With this in hand I got on the only ballistic program I had at the time and started running numbers. I needed the highest retained energy for range of the bullets I had to choose from first. Then once I had this I called the manufacturers of these bullets for the lowest impact velocity which would give full or at least double caliber expansion. For the 140gr weights, this was in the 1600fps range. So now I started load development. I had three bullets which would or were supposed to perform in my range of loads. My finial load was using the 140gr Nosler BT moly coated, which I loaded to 2350fps. The groups were under 1" from a solid rest at 100yds, and all testing done showed great expansion on real targets out to 300yds. Didn't get a deer in WI., could have, my choice, but took a nice fat doe back here at 285yds. At the shot, just behind the left shoulder quartering away, it dumped her on her head and all was done.
Same situation, for 7mm Rem Mag. headed to CO for mule deer and elk. Had no clue as to terrain we would be hunting, never been there before. The area has everything from flat open plain to look up or down 90 degrees. So repeated the process. At the time, there were no AB type bullets out, so I went with the heavies once again. Needed the most velocity, best groups, and highest retained energy at my implimented max range of 600yds. After working through several loads I went with the Hornady 162gr SPBT again moly coated. For the particular load and temps in which it was developed as well as expected temps, the groups were around 1.5" at 300yds. The velocity was 3150fps. out of this particular rifle. Yes it is a smoker but the only time pressure becomes an issue is in temps above 75 degrees. Not a problem for when and where we hunted. Didn't get a chance to try it out on the hunt in CO but have taken several hogs, and this nice buck at 285 yds, no problems.
The Hornady 162gr has done us proud on several long shots out to 400yds on big hogs. Several over 300# have been taken from various angles and all dropped to the shot.
Penetration on this one taken from 350yds, was from right rear ham, blasted through the pelvis, up through and broke the left shoulder and came to rest under the hide just under the jawbone. That is around 3+ feet of tough stuff. I am sure that if you get the 160gr AB's moving at top velocity in your rifle that you will have what your looking for. I would have more than likly went with them had they been out at the time. I tried the PT's, and the XBT's, but couldn't get the accuracy I was looking for.
Good Luck, and remember that in the end, accuracy, and sectional density, will do a lot more for you at the longer ranges and lower velocities than sheer energy numbers. Those long bullets have a knack for plowing through and doing a number on stuff in their way. Just look at the old long 6.5x55, 7x57 and .303 British bullets, that have taken so much game from around the world. It dang sure wasn't from sheer horsepower.