Between pulling the trigger myself and spotting for others I have seen several hundred deer shot with SMK's. Most were with the 168, 175, 190, and 220gr 30cals out of 308's, 300WM's, 300RUM, and a 300
Tomahawk. They work, and most of the time very well, however they can be very unpredictable. Sometimes they yaw very early and fragment violently. Sometimes they will penetrate several inches before upsetting (the vast majority do this in my experience). And sometimes they will penetrate very deeply before they yaw and may or may not expand/fragment.
To give you an idea, here's a visual of what I'm talking about-
(Picture from Dr. Roberts)
The variability between the exact same bullets comes from the tip, or the hollow-point. In the same box of SMK's the opening in the tip has varied from large, to medium, to being almost completely closed due to slivers of copper plugging the hole. This is where the unpredictability comes from.
Here is three deer shot with the same load and gun with similar impact velocity, showing widely varying terminal performance.
Having said that, the only deer that ran was the last and it went about 25 yards I believe.
If it wasn't for AMAX's, SMK's would still be my main bullet for deer, and I would have no qualms about using them again (still use the 220gr in the Tomahawk) however AMAX's and Berger's perform much more consistently in tissue.