This is one of my favorite topics!
It appears that you plan to use the rifle, optic, and load for medium to large game hunting. How often will you shoot that load from the bench? In the field? For things like Groundhogs?
Consider this series of questions that could relate to groundhogs or almost any other similar-size plinking target::
- Do you use this technique in your groundhog shooting?
- If so, how often do you score first round hits out to about 600 yards?
- How does the frequency vary with range?
- How does it change with wind conditions?
- How wild are the first shot misses?
If I'm not mistaken, the groundhog is smaller than the canonical 10" vital zone for deer, but not a bad approximation of the heart and the blood vessels close to it. Hence your frequency of hits on groundhogs could be an indicator of your maximum ethical range (and shooting conditions) for deer and other largish game.
Bottom line: a fair bit of shooting is necessary to become sure that your sighting system is doing what you expect it to be doing. There are surprises!