I would not worry very much about RPM. Light Varmint is gone and with him the vacuum of knowledge about fundamental physics. RPM is both your friend and enemy and you can burn out several barrels determining which or you can just ask any drag racer what happens at 8000+ RPM when something is out of balance in the motor such as will occur when a bullet is deformed upon contact with a bone. Alternatively you can go down to Sears and get some drill bits and shoot them down your barrel being as that was always his favorite saying- a bullet is like a drill bit.
Secondly, the tire will be flat on the bottom even if you kick it and swear at it. In other words what most people find is that it actually takes a long time to learn the nuances of bullet testing and that many bullets will be fired before one understands the end result and can make a prediction. That is why I don't do it.
As you propose, it is a good idea to always keep in the mix a bullet that you know how it performs on large animals such that you have the gold standard.
You can read this article about the Strasbourg goat shooting where they shoot every goat they can find. I thought that they shot 900 goats, but this article only references 50 so maybe 50 had electronic gear on them and the other 850 just fell over when they felt like it. Certainly, it wouldn't be that my memory of the test is faulty. If none of your neighbors have goats you can substitute sheep.
So to sum it up- stick to first principles and if you cannot obey the fundamental and basic laws of physics then it is highly likely something is wrong.
Good luck and have a good time learning about the vagaries of bullets and media.