Quaken, this question was batted around awhile back and perhaps you can find it in the archives, I'm unsure about the title.
I'm guessin your "ultimate" BP rifle in the link above would do the job, and I'm certain it would recoil like a mule with a toothache. That's one helluva lot of powder weight to add to the recoil calculation.
I'm kinda the square peg in the neighborhood on this subject so I won't spend a lot of time here except to say I see little value in today's conventional wisdom about pellets, sabots, and pistol bullets. You might want to check around regarding historical facts about muzzleloader capabilities before all the high-tech crap descended upon us. Try Whitworth Rifle in a search for starters. A .45-50 cal muzzle loader with proper twist will deliver a 450-550 gr. lead conical bullet to 1000 yards or better with substantial leathal force using 90-110 grains of black powder. These ranges are obtainable in these arms because of high BC's and/or low drag coefficients at subsonic velocities. For a given form, BC is proportional to weight, and the form of most ML bullets is essentially the same, excluding HP pistol bullets and their ilk. Accuracy is up to the gun builder and/or your skills and false muzzles aren't a bad way to go but they probably aren't necessary for hunting.
While you're searching cyberspace look up the paper patch link below if you care, also find discussion on Schutzen rifles. There was a fellow some years back riding for the Pony Express that took an Indian Chief at a distance of just less than a mile(surveyed later) with a Sharps Bufflo gun, I'm unable to recall his name at the moment but guess somebody else here will know it.
Lastly, you may recall the devastation inflicted on the buffalo by BP rifles, many if not most of which were Sharps breechloaders. The salient difference between the Sharps and muzzle loaders is which end of the barrel receives bullet and charge first when loading, the charge and bullet weights being essentially the same. None of the shooters of the past used sabots. Good luck regardless of your choice.
[ 04-11-2004: Message edited by: MAX ]