First off lets get all the disclaimers out of the way. The loads I list here are ones that I have used and I make no claims that they will be safe in any other gun.
I use CCI B2 primers with 42 grs RL19 with WIN brass, 80 gr A-Max and get 3300 ft/sec with my 22-250. I use the same load with 75 A-Max and run just under 3400 ft/sec.
The most accurate load I have found is 42 gr RL22 under a berger 80.5 gr running just under 3200 ft/sec.
The 80gr A-Max is the one my wife uses on deer, and yes we can use a 22 cal on deer here. The 80 gr A-max hits very hard out to 400 yards with this load and with a muzzle brake
on it she does not even feel it. I know there can be lots said about the good or bad of a muzzle brake but my wife likes it when she shoots. So all I can say to those that don't like muzzle brakes
is "happy wife , happy life" so I will keep the brake on.
For my 6.5 improved I run 130s at 2950 ft/sec over 52 gr of n165 for hunting out of a 20" barrel and for F class I run 140 JLKs at just over 3000 ft/sec over 52.8 gr of n165. I can go a little faster but can't reach the next accuracy node so I stay around 3000 ft/sec.