Here's a picture of the 338-375 Ruger with some other rounds for comparison.
Left to right: 6mm BR 68gr Berger fb, 308 Win 168 HPBT, 300 WSM 185gr Berger VLD, 338-375 Ruger 250gr MK, 375 BME 350gr MK.
The 338-375 will cycle through a Savage long action with the OAL shown. I haven't played with it much from rifle barrels, but I have a 22" and a 24" barrel I'll chronograph sometime this winter. The rifle barrels I have are just lite weight hunting barrels so I just stuffed a 225gr Accubond over 82.5gr of H4831sc and called it good. Zero at 200 and it's 7" low at 300. Never worried about it further than that from the rifles.