I've killed several Moose with 250 X bullets but nothing like a match bullet, or up real close with the 338wm. Most shots were 350-450 yards with MV on the real high side.
If I was worried Grizz might be around the corner, shoulder shot may be an only option, or something that the 300grs extra weight would be a blessing to have, I'd use it without a doubt. Integrating the 250gr with the R2 would be the best choice for faster no hastle shots and 600 yards and under would be a breeze to reasonably integrate and memmorize.
My 178gr load in the 300 Ultra at 3230 fps when zeroed at 600 yards is also zeroed at 100 and only 4" high at each 200, 300, 400 and 500 yards. Plenty good enough for Moose there! [img]images/icons/cool.gif[/img] After 600, the integration don't work at all, and needs more speed and higher BC to integrate.
For closer LR shots like that on Moose, Bear or whatever large like that, the 225 AB would be the way to go I'd think, good placement or bad.
Considering the 225gr AB would be going quite a bit faster than the 300gr SMK and weighs substantially less, those would be good ones to test and compare at various ranges in water, then in sand/clay. The 300gr may penitrate farther at LR and it's reduced terminal velocity could even out the two in alot of ways. Wish I had some Moose shoulders to shoot through for this test!
I find this a compelling question, especially since I've only seen what happens when the subject Lapua projectile strikes a game animal, but heard volumes about what happens in the same instance with the subject Sierra projectile. Of course, you're initial velocity with the former will be (safely) as much as 200 fps greater than with the latter when fired from a .338 Lapua rig - assuming the barrel is 28" long. Consequently, you will require less adjustment of your settings during those crucial moments. The thing is, Lapua bullets appear to be really soft. The copper and lead of which they are constructed is like clay compared to that of other exceptional match projectiles. I suppose that's why they disintegrate shortly after splashing into mammalian tissue masses. You should have seen the wound I saw this bullet make in an Aoudad - initial velocity was 3050 fps and the animal was lasered at 350 yards. I'm relieved to be able to say I wasn't the one who took the animal even though it was my rifle that was used to do the killing. The tissue destruction was great enough that the shoulder mount ended up looking like s*@#!
If you can see it, then you can hit it!