I just got my .22-250 back from IT&G where I had it re-barreled to .22-250AI. I went with a 26 inch Douglas stainless, fluted barrel. I had a lot of people trying to talk me into a 1-8 twist barrel but went with a 1-12. I talked with the techs at Sierra and they said I'd be fine shooting the 65 grain bullet. Berger recommends a 1-12 for their 62 grain bullet. I shoot mostly 50 or 55grain bullets and I may eventually go to 62 - 65 grain bullet for whitetails. I guess it boils down to what you want to do with the rifle. Personally, I can't see the use in slinging an 80 grain bullet from a .22-250 because of the decrease in velocity. The .22-250 satisfies my need for speed. If I want to shoot a heavier bullet, I'll grab the .243 or a .25/06.
Just my humble opinion and I've been wrong at least one time in my life.