Lots of misinformation here, by comparing the 223 and 22-250 with their twist rates. A 223 with a 10 twist shoots 69's a 22-250 with a 12 twist shoots 69's.
For the 12 twist 22-250 you can shoot the 34 Grain dogtowns all the way up to the 69's. I know I own and shoot one.
The most accurate is the long 60 grain V-max @ 3700+ fps.
The 69's from a 22-250 must be shot at 4,000 elevation to work, as the twist is bordering stability.