I have owned a 22-243AI for quite awhile. It will produce amazing accuracy with the 75gr A-Max. Best group was .625" @ 600 yards laser ranged & witnessed. The rifle was used exclusively to kill PA groundhogs out to 1,000 yards. Many, many extended range kills were made with instant lethality.
Naturally, throat life will be limited with any cartridge with this much case capacity and a .224 bore, particularely if you allow the barrel to get hot or are not maticulous about barrel cleaning.
At about 1,000 rounds I decided to set the barrel back and rechamber. Only this time I rechambered in 22-243 (plain). It is a straight forward operation to neck down .243 Lapua cases and just start shooting - no fireforming which needlessly wastes valuable barrel life. Saves time, saves money and quality match grade dies are MUCH cheaper. The AI version was a learning experience and fun to play with but my advise would be to avoid all the various configurations which require fireforming or special order dies & equiptment.
I might add that a .224 bore cartridge with .243 case capacity (or more) is all but usless with any bullets except the real heavy weights. For lighter bullets you would be much better served with a standard 22-250 or 220 Swift. IMO
My gunsmith was so pleased with the results achieved with this new reamer that he built a rifle for himself. However, he used his rifle for deer hunting. He told me that it was one of his rifles that he enjoyed shooting the most and that it was very effective at harvesting whitetails.