Depends on the size of the things you are trying to hit.
This was at about 450-500 yards, at a 30 degree angle, using the hood of a 4x4 as a rest. Targets (baboons) are pretty darn small.
Using a .30-06 Tikka rifle with handloads, Zeiss Conquest 3-9x40 with #4 German reticle.
Note the baboon to the right of center - ruined his day
Also took some baboons at over 500 yards with the same set up.
YouTube - Baboons in Namibia