Personally I dial every time, unless the correction is really small. +1 on the 5-22 NXS with 56 OBJ. I have this setup on my DE 338 and out to 1500 yards it has been outstanding. At game I wont be going any further than that. I also love the 5x bottom end just in case a shot at 100 yards turns up. You can never guarantee what range the game sticks it head out at. I have the R1. I personally dont feel you get the full benefit of owning a NXS if you dont use the turrets. IMHO ?
Good luck. Good choice on the calibre by the way !
With each step in the bush, you are a step closer.